In 1986, he and Nicoletta Canesi founded Lissoni Associati, a multidisciplinary architecture and design firm based in Milan. This was followed by the opening of the visual communications company Graph.x in 1996 and later by the architecture firms Lissoni Architettura and the New York based Lissoni Inc.
With its multinational staff, the group encompasses all aspects of architecture, interiors and product design, as well as graphics, art direction and corporate identity, extending globally to include hotel, restaurant, residential, corporate, retail and exhibition design.
Piero Lissoni is art director for major brands such as Boffi, De Padova, Lema, Living Divani, and Porro and designs collections for internationally renowned names including Alessi, Cassina, Flos, Glas Italia, Kartell, Kerakoll and Knoll. He has received an array of international awards, amongst which the Good Design Award, the Red Dot Award and the ADI Compasso d’Oro.
Recently completed architectural projects include the Conservatorium Hotel in Amsterdam (2012), the Mamilla Hotel in Jerusalem (2009), renovation of the historic Teatro Nazionale in Milan (2009) and the headquarters and production facilities of Kerakoll Design Lab (2014), Matteograssi (2011), Glas Italia (2010) and Living Divani (2007) in Italy.
Soon to be inaugurated are the Oberoi Resort Al Zorah in Ajman, UAE, two towers for the Swire Hotel Group in Shanghai, exclusive waterfront condos and villas for the Miami Beach Ritz-Carlton Residences, twelve hotels across South Korea for the Shilla Stay Hotel brand, the new Roomers Hotel in Baden-Baden, a boutique hotel on the shores of the Italian lakes, a mixed-use development in central Moscow and a luxury townhouse in Chelsea, New York.